The chemical compound which gives grapfefruit its bitter taste could be used to create a diet pill, a study has indicated.
Research found naringenin, which is described as a flavonoid found in citrus fruit, has a revolutionary effect on the liver making it burn fat instead of storing it after a meal.
This means that without having to change diets or cut out particular foods, a dose of naringenin could prevent weight gain and even help to lose it.
Long-term, the researchers behind the tests believe it would also help obesity sufferers and even fight diabetes because the process also helped balance insulin and glucose levels.
Naringenin is best known as the compound which form in citrus fruit, in particular grapefruit, leading to its bitter taste.
Grapefruit has long been recommended as a good way to control weight but the tests involved far higher doses of naringenin than would be accessible just by eating grapefruit.
It would have to be concentrated into a supplement to have the desired effect for those suffering from Type 2 diabetes, which is also a precursor to cardiovascular disease.
The tests were carried out on mice by a team at the Robarts Research Institute at the University of Western Ontario and published in the journal Diabetes.
Two groups of mice were both fed the equivalent of a Western diet to speed up their "metabolic syndrome" â the process which leads to Type 2 diabetes in human.
The food given to one of the groups was treated with naringenin.
The non-naringenin mice became obese, they developed the metabolic syndrome which saw their cholesterol rise and their bodies become resistant to insulin.
The mice given naringenin did not suffer from these. Any rise in cholesterol was corrected by the naringenin which also 'reprogrammed' the live to burn up fat rather than store it.
Lead researcher Professor Murray Huff added: "Furthermore, the marked obesity that develops in these mice was completely prevented by naringenin.
"What was unique about the study was that the effects were independent of caloric intake, meaning the mice ate exactly the same amount of food and the same amount of fat.
"There was no suppression of appetite or decreased food intake, which are often the basis of strategies to reduce weight gain and its metabolic consequences."
The researchers will now try and develop the compound into a drug which would be both effective and safe for humans to take as a supplement or treatment.
Prof Huff said: "These studies show naringenin, through its insulin-like properties, corrects many of the metabolic disturbances linked to insulin resistance and represents a promising therapeutic approach for metabolic syndrome."
Research found naringenin, which is described as a flavonoid found in citrus fruit, has a revolutionary effect on the liver making it burn fat instead of storing it after a meal.
This means that without having to change diets or cut out particular foods, a dose of naringenin could prevent weight gain and even help to lose it.
Long-term, the researchers behind the tests believe it would also help obesity sufferers and even fight diabetes because the process also helped balance insulin and glucose levels.
Naringenin is best known as the compound which form in citrus fruit, in particular grapefruit, leading to its bitter taste.
Grapefruit has long been recommended as a good way to control weight but the tests involved far higher doses of naringenin than would be accessible just by eating grapefruit.
It would have to be concentrated into a supplement to have the desired effect for those suffering from Type 2 diabetes, which is also a precursor to cardiovascular disease.
The tests were carried out on mice by a team at the Robarts Research Institute at the University of Western Ontario and published in the journal Diabetes.
Two groups of mice were both fed the equivalent of a Western diet to speed up their "metabolic syndrome" â the process which leads to Type 2 diabetes in human.
The food given to one of the groups was treated with naringenin.
The non-naringenin mice became obese, they developed the metabolic syndrome which saw their cholesterol rise and their bodies become resistant to insulin.
The mice given naringenin did not suffer from these. Any rise in cholesterol was corrected by the naringenin which also 'reprogrammed' the live to burn up fat rather than store it.
Lead researcher Professor Murray Huff added: "Furthermore, the marked obesity that develops in these mice was completely prevented by naringenin.
"What was unique about the study was that the effects were independent of caloric intake, meaning the mice ate exactly the same amount of food and the same amount of fat.
"There was no suppression of appetite or decreased food intake, which are often the basis of strategies to reduce weight gain and its metabolic consequences."
The researchers will now try and develop the compound into a drug which would be both effective and safe for humans to take as a supplement or treatment.
Prof Huff said: "These studies show naringenin, through its insulin-like properties, corrects many of the metabolic disturbances linked to insulin resistance and represents a promising therapeutic approach for metabolic syndrome."