The news came as scores of people were killed when rebels unleashed rocket fire on Damascus and President Bashar al-Assad's forces retaliated.
Jordan's military said "dozens of jet fighters" struck Daesh targets on Thursday morning, "hitting training camps of the terrorist groups as well as weapons and ammunition warehouses".
It did not say where the targets were located - Daesh holds swathes of Syria and Iraq - but said they were destroyed and the aircraft returned home safely.
American F-16 and F-22 jets provided security to the Jordanian fighter planes, with additional support from refueling tankers and surveillance aircraft, US officials said.
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